| Achi | 18,000 | Quichean | Guatemala |
| Aguacateco | 20,000 | Ixilan | Guatemala |
| Amuzgo (3 languages) | 33,000 | Oto-Manguean | Guerrero, Oaxaca |
| Black Carib | 100,000 | Maipuran | Belize, Guatemala, Honduras, Nicaragua |
| Bribri | 4,000 | Chibchan | Costa Rica |
| Buglere | 2,500 | Unclassified | Panama |
| Burunca | <10 | Chibchan | Costa Rica |
| Cabécar | 3,000 | Chibchan | Costa Rica |
| Cakchiquel (10 languages) | 450,000 | Quichean | Guatemala |
| Catío (mainly CL) | 15,000 | Choco | Panama |
| Chichimeca Pame (3 languages) | 5,700 | Northern Otopamean | San Luis Potosí, Guanajuato |
| Chicomuceltec | 1,500 | Huastecan | Chiapas |
| Chinanteco (14 languages) | 64,000 | Oto-Manguean | Oaxaca |
| Chocho | 2,500 | Chocho-Popolocan | Oaxaca |
| Chol | 85,000 | Cholan | Chiapas |
| Chontal of Tabasco | 35,000 | Cholan | Tabasco |
| Chorotega (Choluteca) | 0 | Manguean | Costa Rica, El Salvador |
| Chortí | 25,000 | Cholan | Guatemala, Honduras |
| Chuj | 9,000 | Chujean | Chiapas, Guatemala |
| Coahuilteco (also US) | 0 | Unclassified | Coahuila, Nuevo León |
| Cocopa (also US) | 450 | Yuman | Baja California Norte |
| Comecrudo | 0 | Unclassified | Tamaulipas |
| Cora | 15,000 | Corachol | Nayarit |
| Cuicateco (2 lgs) | 20,000 | Mixtecan | Oaxaca |
| Diegueño (also US) | 200 | Yuman | Baja California Norte |
| Embera(also CL) | 10,000 | Choco | Panama |
| Guarijío | 4,000 | Taracahitic | Chihuahua |
| Guatuso (Maléku Jaíka) | 350 | Chibchan | Costa Rica |
| Guaymí | 45,000 | Chibchan | Panama, Costa Rica |
| Huasteco (2 languages) | 73,000 | Huastecan | San Luis Potosí, Veracruz |
| Huave | 13,000 | isolate | Oaxaca |
| Huichol | 12,000 | Corachol | Nayarit, Jalisco |
| Island Carib | 0 | Maipuran | Dominica, St. Vincent and the Grenadines, British West Indies |
| Itzá | 100 | Yucatecan | Belize, Guatemala |
| Ixcateco | 0 | Ixcatec-Chocho | Oaxaca |
| Ixil (3 lg) | 45,000 | Ixilan | Guatemala |
| Jacalteco | 10,000 | Kanjobalan | Chiapas, Guatemala |
| Kanjobal | 80,000 | Kanjobalan | Guatemala |
| Karankawa (also US) | 0 | Unclassified | Tamaulipas |
| Kekchi | 275,000 | Greater Quichean | Guatemala, Belize, El Salvador |
| Kickapoo (also US) | 500 | Algonkian | Coahuila |
| Kiliwi | 60 | Yuman | Baja California Norte |
| Kuna, Paya-Pucuro (also CL) | 700 | Macro-Chibchan | Panama |
| Kuna, San Blas | 35,000 | Unclassified | Panama |
| Lacandón | 550 | Yucatecan | Chiapas |
| Lenca | <10 | Xincan | Honduras, El Salvador |
| Matagalpa | 0 | Misumalpan | Nicaragua |
| Matlatzinca (2 lgs) | 2,000 | Southern Otopamean | México |
| Mayo | 50,000 | Taracahitic | Sonora, Sinaloa |
| Mazahua | 325,000 | Central Otopamean | México, Michoacán |
| Mazateco (5 lgs) | 115,000 | Popolocan | Oaxaca, Veracruz |
| Mískito | 120,000 | Misumalpan | Nicaragua, Honduras |
| Mixe (8 languages) | 50,000 | Mixe-Zoque | Oaxaca |
| Mixteco (32 lgs) | 245,000 | Mixtecan | Guerrero, Oaxaca, Puebla |
| Mocho | 500 | Kanjobalan | Chiapas |
| Monimbo | 0 | Unclassified | Nicaragua |
| Mopan | 8,000 | Yucatecan | Belize, Guatemala |
| Nahuatl (Aztec) (14 languages) | 1,220,000 | Aztecan | Durango, Hidalgo, San Luis Potosi, México, Federal District, Morelos, Michoacán, Guerrero, Puebla, Veracruz, Tabasco |
| Northern Mam | 126,000 | Mamean | Guatemala, Chiapas |
| O'odham (also US) | ? | Pimic | Sonora |
| Opata | 0 | Pimic | Sonora |
| Otomi (9 lgs) | 197,000 | Central Otopamean | Queretaro, Guanajuato, Hidalgo, México, Federal District, Tlaxcala, Puebla, Veracruz |
| Paipai (Akwa'ala) | 240 | Yuman | Baja California Norte |
| Paya | 300 | Unclassified | Honduras |
| Pima Bajo (Nebome) | 900 | Pimic | Sonora |
| Pipil | 20 | Aztecan | El Salvador |
| Pocomam (3 lg) | 28,000 | Pokom | Guatemala |
| Pokomchí (2 lg) | 45,000 | Pokom | Guatemala |
| Popoloca (6 lg) | 26,000 | Chocho-Popolocan | Puebla |
| Popoluca (4 languages) | 33,000 | Mixe-Zoque | Veracruz |
| Quiché (9 languages) | 900,000 | Quichean | Guatemala |
| Rama | 20 | Chibchan | Nicaragua |
| Seri | 500 | Hokan | Sonora |
| Subtiaba | 0 | Southern Hokan | Nicaragua |
| Sumo | 7,200 | Misumalpan | Nicaragua, Honduras |
| Tacaneco | 5,000 | Southern Mam | Chiapas, Guatemala |
| Tarahumara | 8,000 | Taracahitic | Chihuahua |
| Tarasco | 60,000 | Tarascan | Michoacán |
| Tectiteco | 2,000 | Southern Mam | Chiapas, Guatemala |
| Tepecano | 0 | Pimic | Jalisco |
| Tepehua (3 languages) | 8,500 | Totonacan | Hidalgo, Puebla, Veracruz |
| Tepehuan (3 lgs) | 16,500 | Pimic | Chihuahua, Durango |
| Tequistlateco | 5,000 | Tequistlatecan | Oaxaca |
| Teribe (Naso) | 1,000 | Chibchan | Panama, Costa Rica |
| Tipai | 185 | Yuman | Baja California Norte |
| Tlamelula Chontal | 4,500 | Tequistlatecan | Oaxaca |
| Tlapaneco | 40,000 | Southern Hokan | Guerrero |
| Tojolabal | 13,000 | Chujean | Chiapas |
| Tol (Jicaque) | 300 | Southern Hokan | Honduras |
| Totonaco (6 languages) | 260,000 | Totonacan | Puebla, Veracruz |
| Trique (3 languages) | 16,000 | Mixtecan | Oaxaca |
| Tubar | 0 | Taracahitic | Chihuahua |
| Tzeltal (2 lg) | 45,000 | Tzeltalan | Chiapas |
| Tzotzil | 110,000 | Tzeltalan | Chiapas |
| Tzutujil (2 lg) | 26,000 | Greater Quichean | Guatemala |
| Uspanteco | 1,000 | Greater Quichean | Guatemala |
| Waunana (also CL) | 4,000 | Choco | Panama |
| Xinca | 0 | Xincan | Guatemala |
| Yaqui (also US) | 12,000 | Taracahitic | Sonora |
| Yucateco (Maya) | 500,000 | Yucatecan | Campeche, Yucatán, Quintana Roo, Belize |
| Zapoteco (40+ languages) | 350,000 | Oto-Manguean | Oaxaca |
| Zoque (5 languages) | 18,000 | Mixe-Zoque | Chiapas, Oaxaca |